HMG-CoA Reductase (HMGCR)

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HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate. HMGCR is found in eukaryotes and prokaryotes. The phylogenetic analysis has revealed two classes of HMG-CoA reductase, the Class I enzymes of eukaryotes and some archaea and the Class II enzymes of eubacteria and certain other archaea.

Both in eukaryotes and in archaebacteria the enzyme HMGCR is known to catalyze an early reaction unique to isoprenoid biosynthesis. In humans, the HMG-CoA reductase reaction is rate-limiting for the biosynthesis of cholesterol and therefore constitutes a prime target of drugs that reduce serum cholesterol levels.

HMG-CoA Reductase (HMGCR) 관련 제품 (158)
Antibodies (13)

By Effects:	Inhibitors (136) Degrader (1) Controls (6) Substrate (1)

Cat. No.	상품명	효과	Purity	Chemical Structure

HY-17504D

(3S,5R)-Rosuvastatin	Inhibitor
(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC₅₀ of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

HY-N0504S2

Lovastatin-d₃	Inhibitor
Lovastatin-d₃ is deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-155668

HMG-CoA Reductase-IN-1	Inhibitor
HMG-CoA Reductase-IN-1 is a HMG-CoA reductase inhibitor. HMG-CoA Reductase-IN-1has high HMGR inhibitory activity and OATP1B1 affinity with pIC₅₀ and pKm values of 8.54 and 1.98, respectively. HMG-CoA Reductase-IN-1 can be used for the research of hypercholesterolemia.

HY-11088

PF-3052334	Inhibitor
PF-3052334 is an orally active, hepatically selective HMG-CoA reductase inhibitor with an IC₅₀ of 1.9 nM. PF-3052334 inhibits cholesterol synthesis, with IC₅₀ values of 0.9 and 730 nM in hepatocytes and muscle cells, respectively. PF-3052334 can be used to study hypercholesterolemia.

HY-19107

SQ-33600	Inhibitor
SQ-33600 is an HMG-CoA reductase inhibitor. SQ-33600 has cholesterol-lowering activity. SQ-33600 possesses cell-type selectivity, with much higher inhibitory activity on rat hepatocytes (IC₅₀: 93 nM) than on human skin fibroblasts (IC₅₀: 14200 nM). SQ-33600 can be used in the research of diseases such as hypercholesterolemia.

HY-N11637A

(Z)-Ganoderenic acid K	Control
(Z)-Ganoderenic acid K is a triterpene acid that can be isolated from the basidiocarp of Ganoderma lucidum. Ganoderenic acid K (HY-N11637), the isomer of (Z)-Ganoderenic acid K, is a HMG-CoA reductase (HMGCR) inhibitor with an IC₅₀ of 16.5 μM.

HY-101873R

Atorvastatin lactone (Standard)	Inhibitor
Atorvastatin lactone (Standard) is the analytical standard of Atorvastatin lactone. This product is intended for research and analytical applications. Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.

HY-W740010

N-Desmethyl rosuvastatin disodium hydrate	Inhibitor	99.1%
N-Desmethyl rosuvastatin disodium hydrate is an active metabolite of HMG-CoA reductase (HMGCR) inhibitor rosuvastatin (HY-17504). N-Desmethyl rosuvastatin disodium hydrate can be utilized in research of rosuvastatin metabolism.

HY-16152

Crilvastatin	Inhibitor
Crilvastatin (PMD 387) is a potent inhibitor of HMG-CoA reductase.

HY-N18304

Brutieridin	Inhibitor
Brutieridin (Compound 1) is a flavanone glycoside that can be isolated from the juice of bergamot (Citrus bergamia). Brutieridin reduces the level of NPC1L1 in intestinal epithelial cells. Brutieridin decreases cholesterol uptake by intestinal epithelial cells. Brutieridin reduces HMGR activity. Brutieridin can be used in the research of hypercholesterolemia.

HY-109523S

Cerivastatin-d₃ sodium	Inhibitor
Cerivastatin-d₃ sodium is deuterated labeled Cerivastatin sodium (HY-109523). Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect.

HY-135358

(Rac)-5-Keto Fluvastatin	Inhibitor
(Rac)-5-Keto Fluvastatin (3-Hydroxy-5-Keto Fluvastatin) is an impurity of Fluvastatin (XU 62320). Fluvastatin is a HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM.

HY-135402

2'-Ethyl Simvastatin	Inhibitor
2'-Ethyl Simvastatin (compound 6) is a Mevinolin analog, with HMG-CoA reductase inhibition.

HY-RS06240

Hmgcr Rat Pre-designed siRNA Set A	Inhibitor
Hmgcr Rat Pre-designed siRNA Set A contains three designed siRNAs for Hmgcr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-117581

L-669,262	Inhibitor
L-669,262, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, with an IC₅₀ of 0.10 ng/mL for rat liver HMG-CoA.

HY-123672R

Lovastatin hydroxy acid sodium (Standard)	Inhibitor
Lovastatin hydroxy acid (sodium) (Standard) is the analytical standard of Lovastatin hydroxy acid (sodium). This product is intended for research and analytical applications. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM.

HY-183967

CNP7
CNP7 is a covalent, selective HMGCS1 inhibitor. CNP7 reduces intracellular HMG-CoA levels. CNP7 induces global protein deisoprenylation. CNP7 exhibits a cell line-specific pattern of anticancer activity. CNP7 is applicable for cancer research.

HY-17408R

Mevastatin (Standard)	Inhibitor
Mevastatin (Standard) is the analytical standard of Mevastatin. This product is intended for research and analytical applications. Mevastatin (Compactin) is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G₀/G₁ phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment.

HY-14664B

(3R,5S)-Fluvastatin	Inhibitor
(3R,5S)-Fluvastatin is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC₅₀ of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.

HY-B0144S

Pitavastatin-d₄ hemicalcium	Inhibitor
Pitavastatin-d₄ (hemicalcium) is deuterium labeled Pitavastatin (Calcium). Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity[1][2][3].

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HMG-CoA Reductase (HMGCR)

HMG-CoA Reductase (HMGCR)

HMG-CoA Reductase (HMGCR) 관련 제품 (158)

Antibodies (13)

HMG-CoA Reductase (HMGCR) 관련 제품 (158):